You apply Six Sigma in the same way as any other business enterprise.  In general, this means you must implement Six Sigma on a project-by-project basis.  Generically speaking, Y=f(X) and the only thing that changes from situation-to-situation is the variable labels, transfer function, rate of replication, cost-per-transaction,  and faces of the players.  Other than that,  everything else is “made from the mold,” so to speak.